Molecular Docking Study of Four Chromene Derivatives as Novel HIV-1 Integrase Inhibitors

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dc.contributor.authorArslan, Nevin
dc.date.accessioned2021-08-03T08:06:31Z
dc.date.available2021-08-03T08:06:31Z
dc.date.issued2019
dc.departmentFakülteler, Ziraat Fakültesi, Gıda Mühendisliği Bölümüen_US
dc.description.abstract: Four ligands based on Chromene derivatives have been docked into integrase of prototype foamy virus, which has high structural similarity with that of HIV-1 integrase. The Autodock Vina (Vina) software was used for this purpose. The docking scores for the derivatives are -7.3 kcal/mol, -7.5 kcal/mol, -6.9 kcal/mol, and -7.2 kcal/mol, respectively, which are comparable with that for Raltegravir (-10.7 kcal/mol). The docking results provide a detailed evidence for the interactions of four Chromene derivatives. The results may lead to the design and development of new drug candidates against AIDSen_US
dc.identifier.citationARSLAN, N. (2019). Molecular Docking Study of Four Chromene Derivatives as Novel HIV-1 Integrase Inhibitors. Journal of the Turkish Chemical Society Section A: Chemistry, 6(2), 133–142.en_US
dc.identifier.doi10.18596/jotcsa.478772
dc.identifier.endpage142en_US
dc.identifier.issue2en_US
dc.identifier.orcid0000-0003-0142-9215
dc.identifier.scopus2-s2.0-85070497848
dc.identifier.scopusqualityQ4
dc.identifier.startpage133en_US
dc.identifier.trdizinid396141
dc.identifier.urihttps://dergipark.org.tr/en/download/article-file/664132
dc.identifier.urihttps://hdl.handle.net/11503/1241
dc.identifier.urihttps://doi.org10.18596/jotcsa.478772
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakScopus
dc.institutionauthorArslan, Nevin
dc.language.isoen
dc.publisherJournal of the Turkish Chemical Society, Section A: Chemistryen_US
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAIDSen_US
dc.subjectChromene derivativesen_US
dc.subjectMolecular dockingen_US
dc.subjectHIV-1 integrase inhibitorsen_US
dc.titleMolecular Docking Study of Four Chromene Derivatives as Novel HIV-1 Integrase Inhibitorsen_US
dc.typeArticle

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